Title of article
Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity
Author/Authors
Baihua Hu، نويسنده , , Elaine Quinet، نويسنده , , Rayomand Unwalla، نويسنده , , Mike Collini، نويسنده , , James Jetter، نويسنده , , Rebecca Dooley، نويسنده , , Diane Andraka، نويسنده , , Lisa Nogle، نويسنده , , Dawn Savio، نويسنده , , Anita Halpern، نويسنده , , Annika Goos-Nilsson، نويسنده , , Anna Wilhelmsson، نويسنده , , Ponnal Nambi، نويسنده , , Jay Wrobel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
54
To page
59
Abstract
A series of potent and binding selective LXRβ agonists was developed using the previously reported non-selective LXR ligand WAY-254011 as a structural template. With the aid of molecular modeling, it was found that 2,3-diMe-Ph, 2,5-diMe-Ph, and naphthalene substituted quinoline acetic acids (such as quinoline 33, 37, and 38) showed selectivity for LXRβ over LXRα in binding assays.
Keywords
LXR agonists , Quinolines , Carboxylic acids , Selectivity in binding assays
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798919
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