Title of article
1-Toluene-sulfonyl-3-[(3′-hydroxy-5′-substituted)-γ-butyrolactone]-indoles: Synthesis, COX-2 inhibition and anti-cancer activities
Author/Authors
Palwinder Singh، نويسنده , , Anu Mittal، نويسنده , , Atul Bhardwaj، نويسنده , , Satwinderjeet Kaur، نويسنده , , Subodh Kumar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
85
To page
89
Abstract
Indoles carrying a cyclic ester (γ-butyrolactone) at C-3 position have been synthesized by the allylation of 3-indoleglyoxylate followed by iodocyclisation and the nucleophilic replacement of the iodo-group. Screening of these molecules for COX-2 inhibition and anti-cancer activities has identified compounds 10 and 11 as highly potent and selective for COX-2 as well as showing remarkable anti-cancer activities (better than that of indomethacin).
Keywords
COX-2 inhibition , Dockings , Anti-cancer activities , indole , Butyrolactone , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798924
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