Title of article
(2S,2′R)-Analogue of LG190178 is a major active isomer
Author/Authors
Wataru Hakamata، نويسنده , , Yukiko Sato، نويسنده , , Haruhiro Okuda، نويسنده , , Shinobu Honzawa، نويسنده , , Nozomi Saito، نويسنده , , Seishi Kishimoto، نويسنده , , Atsushi Yamashita، نويسنده , , Takayuki Sugiura، نويسنده , , Atsushi Kittaka، نويسنده , , Masaaki Kurihara، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
120
To page
123
Abstract
Vitamin D receptor (VDR) ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. VDR ligands also show immense potential as therapeutic agents for autoimmune diseases and cancers of the skin, prostate, colon, and breast as well as leukemia. LG190178 is a novel non-secosteroidal ligand for VDR. We synthesized and evaluated stereoisomers of LG190178 and found that only an (2S,2′R)-analogue of LG190178 (YR301) had strong activity.
Keywords
YR301 , Vitamin D receptor , Non-secosteroidal ligand , (2S , 2?R)-LG190178
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798931
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