Title of article :
(2S,2′R)-Analogue of LG190178 is a major active isomer
Author/Authors :
Wataru Hakamata، نويسنده , , Yukiko Sato، نويسنده , , Haruhiro Okuda، نويسنده , , Shinobu Honzawa، نويسنده , , Nozomi Saito، نويسنده , , Seishi Kishimoto، نويسنده , , Atsushi Yamashita، نويسنده , , Takayuki Sugiura، نويسنده , , Atsushi Kittaka، نويسنده , , Masaaki Kurihara، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Vitamin D receptor (VDR) ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. VDR ligands also show immense potential as therapeutic agents for autoimmune diseases and cancers of the skin, prostate, colon, and breast as well as leukemia. LG190178 is a novel non-secosteroidal ligand for VDR. We synthesized and evaluated stereoisomers of LG190178 and found that only an (2S,2′R)-analogue of LG190178 (YR301) had strong activity.
Keywords :
YR301 , Vitamin D receptor , Non-secosteroidal ligand , (2S , 2?R)-LG190178
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
