Title of article
Sulfonate chalcone as new class voltage-dependent K+ channel blocker
Author/Authors
Oleg V. Yarishkin، نويسنده , , Hyung Won Ryu، نويسنده , , Jae-Yong Park، نويسنده , , Min Suk Yang، نويسنده , , Seonggeun Hong، نويسنده , , Ki Hun Park، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
137
To page
140
Abstract
Chalcone derivatives 1–17 were synthesized and their voltage-dependent K+channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9–17, in which the sulfonyloxy group is placed on the A-ring. The 3′-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51 ± 0.05 μM) was the most potent K+ channel blocker.
Keywords
Chalcone , Sulfonate chalcone , K+ channel blocker , potassium channel blocker , ion channel
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798934
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