Title of article :
Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3
Author/Authors :
Aline Moulin، نويسنده , , Luc Demange، نويسنده , , Joanne Ryan، نويسنده , , Céline M’Kadmi، نويسنده , , Jean-Claude Galleyrand، نويسنده , , Jean Martinez، نويسنده , , Jean-Alain Fehrentz، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The synthesis and structure–activity relationships concerning 3,4,5-trisubstituted 1,2,4-triazoles as ghrelin receptor ligands are described. The importance of the starting aminoacid material as well as its configuration was explored and the (d) Trp residue was found to lead to the best agonist or antagonist compounds.
Keywords :
agonist , GHS-R1a , 1 , Antagonist , 4-Triazole , 2 , Trisubstituted 1 , 4-Triazoles , Ghrelin receptor ligands , ghrelin , 2
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
