Title of article :
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation
Author/Authors :
Jens-Uwe Peters، نويسنده , , Thomas Lübbers، نويسنده , , Alexander Alanine، نويسنده , , Sabine Kolczewski، نويسنده , , Francesca Blasco، نويسنده , , Lucinda Steward، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
6
From page :
256
To page :
261
Abstract :
The optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.
Keywords :
5-HT , GPCR , SAR , guanidine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
798958
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=798958
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