Title of article :
4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity
Author/Authors :
Luigi Scipione، نويسنده , , Daniela De Vita، نويسنده , , Alessandra Musella، نويسنده , , Lisa Flammini، نويسنده , , Simona Bertoni، نويسنده , , Elisabetta Barocelli، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.
Keywords :
4-Aminopyridine derivatives , Acetylcholinesterase , Butyrylcholinesterase , Antiamnesic effects
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
