Title of article :
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
Author/Authors :
Diana L. Nersesian، نويسنده , , Lawrence A. Black، نويسنده , , Thomas R. Miller، نويسنده , , Timothy A. Vortherms، نويسنده , , Timothy A. Esbenshade، نويسنده , , Arthur A. Hancock، نويسنده , , Marlon D. Cowart، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Structure–activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
Keywords :
Histamine H3 , Serotonin , ADHD , Imidazoles
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
