Title of article
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
Author/Authors
Diana L. Nersesian، نويسنده , , Lawrence A. Black، نويسنده , , Thomas R. Miller، نويسنده , , Timothy A. Vortherms، نويسنده , , Timothy A. Esbenshade، نويسنده , , Arthur A. Hancock، نويسنده , , Marlon D. Cowart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
355
To page
359
Abstract
Structure–activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
Keywords
Histamine H3 , Serotonin , ADHD , Imidazoles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798977
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