Title of article :
Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors
Author/Authors :
Jeffrey-Tri Nguyen، نويسنده , , Meihui Zhang، نويسنده , , Henri-Obadja Kumada، نويسنده , , Ayako Itami، نويسنده , , Keiji Nishiyama، نويسنده , , Tooru Kimura، نويسنده , , Maosheng Cheng، نويسنده , , Yoshio Hayashi، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The culprit behind adult T-cell leukemia, myelopathy/tropical paraparesis, and a plethora of inflammatory diseases is the human T-cell leukemia virus type 1 (HTLV-I). We recently unveiled a potent hexapeptidic HTLV-I protease inhibitor, KNI-10166, composed mostly of natural amino acid residues. Herein, we report the derivation of potent tetrapeptidic inhibitor KNI-10516, possessing only non-natural amino acid residues.
Keywords :
Adult T-cell leukemia , Human T-cell leukemia virus , Human immunodeficiency virus , protease inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
