Title of article
Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationships
Author/Authors
Tetsuji Hosono، نويسنده , , Kazumi Yokomizo، نويسنده , , Akiyuki Hamasaki، نويسنده , , Yoshinari Okamoto، نويسنده , , Tadashi Okawara، نويسنده , , Masami Otsuka، نويسنده , , Ryozaburo Mukai، نويسنده , , Keitarou Suzuki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
371
To page
374
Abstract
The compound named Histidine–pyridine–histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 μM, and relatively high cytotoxicity with a CC50 of 37 μM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 μM, but exhibited a far more less cytotoxicity (CC50 500 μM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities.
Keywords
structure–activity relationship , HPH , Antiviral activity , Herpes simplex virus type 1 , Histidine–pyridine–histidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798980
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