Author/Authors :
Tim Sparey، نويسنده , , Earl Clarke، نويسنده , , Joanne Hannam، نويسنده , , Timothy Harrison، نويسنده , , Andrew Madin، نويسنده , , Mark Shearman، نويسنده , , Bindi Sohal، نويسنده ,
Abstract :
Bridgehead substituted derivatives of bicyclo[4.2.1]nonanes were synthesized and shown to be potent inhibitors of γ-secretase. Two related series were synthesized to explore the SARs. More potent compounds were found in the non-benzofused series compared with the benzofused series. One compound from each series showed good exposure in the hepatic portal vein (HPV) following oral dosing to rats.
