Title of article
Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase
Author/Authors
Carl P. Bergstrom، نويسنده , , Charles P. Sloan، نويسنده , , Wai-Yu Lau، نويسنده , , David W. Smith، نويسنده , , Ming Zheng، نويسنده , , Steven B. Hansel، نويسنده , , Craig T. Polson، نويسنده , , Jason A. Corsa، نويسنده , , Donna M. Barten، نويسنده , , Kevin M. Felsenstein، نويسنده , , Susan B. Roberts، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
464
To page
468
Abstract
The synthesis and γ-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain Aβ in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2.
Keywords
Amyloid-? , sulfonamides , Alzheimer’s Disease , Secretase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798996
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