Title of article :
A method for the synthesis of an oseltamivir PET tracer
Author/Authors :
Masataka Morita، نويسنده , , Toshihiko Sone، نويسنده , , Kenzo Yamatsugu، نويسنده , , Yoshihiro Sohtome، نويسنده , , Shigeki Matsunaga، نويسنده , , Motomu Kanai، نويسنده , , Yasuyoshi Watanabe، نويسنده , , Masakatsu Shibasaki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A protocol applicable for the synthesis of an oseltamivir positron emission tomography (PET) tracer was developed. Acetylation of amine 3 with CH3COCl, followed by deprotection and aqueous workup, produced oseltamivir 4 from 3 within 10 min. The obtained 4 was sufficiently pure for PET studies. This method can be extended to PET tracer synthesis using CH311COCl.
Keywords :
Oseltamivir , Positron emission tomography (PET) , Influenza , acetylation , Neuroexcitatory effects
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
