Title of article
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor α agonists
Author/Authors
Nicolas Faucher، نويسنده , , Paul Martres، نويسنده , , Alain Laroze، نويسنده , , Pierre-Olivier Pineau، نويسنده , , Florent Potvain، نويسنده , , Didier Grillot، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
710
To page
715
Abstract
Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARα agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported.
Keywords
Peroxisome proliferator-activated receptors , Fibrate , Trifluoromethane sulfonamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799045
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