Title of article :
Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?
Author/Authors :
Voula Mitsakos، نويسنده , , Renwick C.J. Dobson، نويسنده , , F. Grant Pearce، نويسنده , , Sean R. Devenish، نويسنده , , Genevieve L. Evans، نويسنده , , Benjamin R. Burgess، نويسنده , , Matthew A. Perugini، نويسنده , , Juliet A. Gerrard، نويسنده , , Craig A. Hutton، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable.
Keywords :
DHDPS , Species specificity , Antibacterials , N-Acetylneuraminate lyase , Dihydrodipicolinate synthase , NAL
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
