Title of article
The design, synthesis and structure–activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists
Author/Authors
Taeyoung Yoon، نويسنده , , Stéphane De Lombaert، نويسنده , , Robbin Brodbeck، نويسنده , , Michael Gulianello، نويسنده , , Jayaraman Chandrasekhar، نويسنده , , Raymond F. Horvath، نويسنده , , Ping Ge، نويسنده , , Mark T. Kershaw، نويسنده , , James E. Krause، نويسنده , , John Kehne، نويسنده , , Diane Hoffman-Kim، نويسنده , , Dario Doller، نويسنده , , Kevin J. Hodgetts، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
891
To page
896
Abstract
The design, synthesis and structure–activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated.
Keywords
Anxiety , CRF-1 receptor antagonist , 1-Aryl-4-aminoalkylisoquinoline , depression
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799078
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