Title of article
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems
Author/Authors
Fabrizio Micheli، نويسنده , , Giorgio Bonanomi، نويسنده , , Simone Braggio، نويسنده , , Anna Maria Capelli، نويسنده , , Paolo Celestini، نويسنده , , Federica Damiani، نويسنده , , Romano Di Fabio، نويسنده , , Daniele Donati، نويسنده , , Stefania Gagliardi، نويسنده , , MARIA GABRIELLA GENTILE، نويسنده , , Dieter Hamprecht، نويسنده , , Marcella Petrone، نويسنده , , Stefano Radaelli، نويسنده , , Giovanna Tedesco، نويسنده , , Silvia Terreni، نويسنده , , Angela Worby، نويسنده , , Christian Heidbreder، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
901
To page
907
Abstract
The synthesis and SAR of a new series of potent and selective dopamine D3 receptor antagonists is reported. The introduction of a tricyclic [h]-fused benzazepine moiety on the recently disclosed scaffold of 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines is reported. A full rat pharmacokinetic characterization is also reported.
Keywords
DMPK , SAR , In Vivo , in vitro , D3 antag , Rat , Selective
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799081
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