Title of article
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains
Author/Authors
Anand Mayasundari، نويسنده , , Antonio M. Ferreira، نويسنده , , Liwen He، نويسنده , , Neeraj Mahindroo، نويسنده , , Don Bashford، نويسنده , , Naoaki Fujii، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
942
To page
945
Abstract
This report describes the first small-molecule antagonists that specifically target the ligand-binding pocket of PDZ domains of NHERF1 multi-functional adaptor protein. Comparison of the peptide sequence homology between the native ligand of NHERF1 PDZ domains and an indole-based non-peptide chemical scaffold allowed the design of a small-molecule antagonist of NHERF1 PDZ domains.
Keywords
EBP50 , NHERF1 , PDZ domain , Protein–protein interaction inhibitor , Indole , Small molecule
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799089
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