Title of article :
Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors
Author/Authors :
Richard Ducray، نويسنده , , Peter Ballard، نويسنده , , Bernard C. Barlaam، نويسنده , , Mark D. Hickinson، نويسنده , , Jason G. Kettle، نويسنده , , Donald J. Ogilvie، نويسنده , , Catherine B. Trigwell، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Novel 4-anilino-1H-pyrazolo[3,4-d]pyrimidines have been synthesized and evaluated in vitro for erbB2 and EGFR kinase inhibition. A representative compound displaying oral bioavailability in rat and dog illustrates the potential of this series to provide orally active erbB2 inhibitors.
Keywords :
Pyrazolopyrimidines , Receptor tyrosine kinase , ErbB2
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
