Title of article
Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists
Author/Authors
Alexander Pasternak، نويسنده , , Stephen D. Goble، نويسنده , , Pasquale P. Vicario، نويسنده , , Jerry Di Salvo، نويسنده , , Julia M. Ayala، نويسنده , , Mary Struthers، نويسنده , , Julie A. DeMartino، نويسنده , , Sander G. Mills، نويسنده , , Lihu Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
994
To page
998
Abstract
This report describes replacement of the 4-(4-fluorophenyl)piperidine moiety in our CCR2 antagonists with 4-heteroaryl piperidine and 4-(carboxyphenyl)-piperidine subunits. Some of the resulting analogs retained potency in our CCR2 binding assay and had improved selectivity versus the IKr channel; poor selectivity against IKr had been a liability of earlier analogs in this series.
Keywords
Antagonist , CCR2 , chemokine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799100
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