Author/Authors :
Richard L. Mackman، نويسنده , , Kuei-Ying Lin، نويسنده , , Constantine G. Boojamra، نويسنده , , Hon Hui، نويسنده , , Janet Douglas، نويسنده , , Deborah Grant، نويسنده , , Oleg Petrakovsky، نويسنده , , Vidya Prasad، نويسنده , , Adrian S. Ray، نويسنده , , Tomas Cihlar، نويسنده ,
Abstract :
Modified purine analogs of GS-9148 [5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (2′-Fd4AP) were synthesized and their anti-HIV potency evaluated. The antiviral activity of guanosine analog (2′-Fd4GP) was comparable that of to 2′-Fd4AP in MT-2 cells, but selectivity was reduced.
