Title of article
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 2. Optimization of α-amino substituents
Author/Authors
Shyh-Ming Yang، نويسنده , , Robert H. Scannevin، نويسنده , , Bingbing Wang، نويسنده , , Sharon L. Burke، نويسنده , , Zhihong Huang، نويسنده , , Prabha Karnachi، نويسنده , , Lawrence J. Wilson، نويسنده , , Kenneth J. Rhodes، نويسنده , , Bharat Lagu، نويسنده , , William V. Murray، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
1140
To page
1145
Abstract
The introduction and the optimization of an α-amino substituent based on a series of α-hydroxy-β-N-biaryl ether sulfonamide hydroxamates is described. The modification leads to a new series of MMP-2/MMP-9 inhibitors with enhanced inhibitory activities and improved ADME properties. An efficacy study on reducing the ischemia-induced brain edema in the rat transient middle cerebral artery occlusion (tMCAo) model is also demonstrated.
Keywords
Gelatinase , matrix metalloproteinase , MMP inhibitor , Hydroxamate , stroke
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799129
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