Title of article
Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A
Author/Authors
Gang Cheng، نويسنده , , Shukun Li، نويسنده , , Jingya Li، نويسنده , , Youhong Hu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1177
To page
1180
Abstract
A novel one-pot synthesis of 2,4-substituted 5-azolylthiopyrimidines is achieved by sequential Michael-addition of 3-iodochromones with mercaptoazole (or mercaptotriazoles) and then condensation with a variety of amidines. Compound A1B6C1 exhibits a potent anti-influenza virus A activity with an IC50 value of 21.56 mg/mL and SI value of 9.
Keywords
one-pot synthesis , Michael-addition , condensation , 5-Azolylthiopyridines , Heterocycle libraries , Anti-influenza
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799136
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