Title of article
The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists
Author/Authors
Alan D. Brown، نويسنده , , Mark E. Bunnage، نويسنده , , Paul A. Glossop، نويسنده , , Kim James، نويسنده , , Rhys Jones، نويسنده , , Charlotte A.L. Lane، نويسنده , , Russell A. Lewthwaite، نويسنده , , Simon Mantell، نويسنده , , Christelle Perros-Huguet، نويسنده , , David A. Price، نويسنده , , Mike Trevethick، نويسنده , , Rob Webster، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1280
To page
1283
Abstract
The design and profile of a series of adamantyl-containing long acting β2-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using a guinea pig trachea tissue model. A focus was then placed on developing a robust synthetic route to ensure rapid delivery of material for clinical trials.
Keywords
?2 , Adrenoreceptor , Saligenin , asthma , Crystalline , Adamantyl
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799151
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