Title of article
Identification of a potent new chemotype for the selective inhibition of PDE4
Author/Authors
Amanda P. Skoumbourdis، نويسنده , , Ruili Huang، نويسنده , , Noel Southall، نويسنده , , William Leister، نويسنده , , Vicky Guo، نويسنده , , Ming-Hsuang Cho، نويسنده , , James Inglese، نويسنده , , Marshall Nirenberg، نويسنده , , Christopher P. Austin، نويسنده , , Menghang Xia، نويسنده , , Craig J. Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
1297
To page
1303
Abstract
A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure–activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.
Keywords
COPD , 4-Catechol diether , 3 , PDE4
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799155
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