Author/Authors :
Chen Chen، نويسنده , , Brian Dyck، نويسنده , , Beth A. Fleck، نويسنده , , Alan C. Foster، نويسنده , , Jonathan Grey، نويسنده , , Florence Jovic، نويسنده , , Michael Mesleh، نويسنده , , Kasey Phan، نويسنده , , Junko Tamiya، نويسنده , , Troy Vickers، نويسنده , , Mingzhu Zhang، نويسنده ,
Abstract :
Derivatives of milnacipran were synthesized and studied as monoamine transporter inhibitors. Potent analogs were discovered at NET (9k) and at both NET and SERT (9s and 9u). A pharmacophore model was established based on the conformational analysis of milnacipran in aqueous solution using NMR techniques and was consistent with the SAR results.
Keywords :
Pharmacophore , milnacipran , Structure–activity relationship , Norepinephrine , Serotonin , Monoamine transporter , inhibitor , synthesis
