Title of article
Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors
Author/Authors
Chen Chen، نويسنده , , Brian Dyck، نويسنده , , Beth A. Fleck، نويسنده , , Alan C. Foster، نويسنده , , Jonathan Grey، نويسنده , , Florence Jovic، نويسنده , , Michael Mesleh، نويسنده , , Kasey Phan، نويسنده , , Junko Tamiya، نويسنده , , Troy Vickers، نويسنده , , Mingzhu Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1346
To page
1349
Abstract
Derivatives of milnacipran were synthesized and studied as monoamine transporter inhibitors. Potent analogs were discovered at NET (9k) and at both NET and SERT (9s and 9u). A pharmacophore model was established based on the conformational analysis of milnacipran in aqueous solution using NMR techniques and was consistent with the SAR results.
Keywords
Pharmacophore , milnacipran , Structure–activity relationship , Norepinephrine , Serotonin , Monoamine transporter , inhibitor , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799164
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