Author/Authors :
Igor V. Magedov، نويسنده , , Giovanni Luchetti، نويسنده , , Nikolai M. Evdokimov، نويسنده , , Madhuri Manpadi، نويسنده , , Wim F.A. Steelant، نويسنده , , Severine Van slambrouck، نويسنده , , Paul Tongwa، نويسنده , , Mikhail Yu. Antipin، نويسنده , , Alexander Kornienko، نويسنده ,
Abstract :
Diversely substituted 2-pyrrolines have been prepared by a novel multicomponent process involving a reaction of various N-(aryl- and alkylsulfonamido)-acetophenones with aldehydes and malononitrile. While the reaction is highly regioselective, it is not stereoselective, generating a mixture of cis and trans 2-pyrrolines. A number of analogs from both cis and trans 2-pyrroline libraries were found to have antiproliferative activity in human cancer cell lines.
Keywords :
Multicomponent synthesis , Apoptosis , Heterocycles , Antiproliferative
