Author/Authors :
Adrian Hall، نويسنده , , Rino A. Bit، نويسنده , , Susan H. Brown، نويسنده , , Anita Chowdhury، نويسنده , , Gerard M.P. Giblin، نويسنده , , David N. Hurst، نويسنده , , Ian R. Kilford، نويسنده , , Xiao Lewell، نويسنده , , Alan Naylor، نويسنده , , Tiziana Scoccitti، نويسنده ,
Abstract :
We describe the SAR, in terms of heterocyclic replacements, for a series of pyrazole EP1 receptor antagonists. This study led to the identification of several aromatic heterocyclic replacements for the pyrazole in the original compound. Investigation of replacements for the methylene linker uncovered disparate SAR in the thiazole and pyridine series.
Keywords :
Pyrazole , EP1 antagonist , isostere , Heterocycle
