Title of article :
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1′ modifications for the exploration of the S1′ subsite
Author/Authors :
David N. Deaton، نويسنده , , Kevin P. Graham، نويسنده , , Jeffrey W. Gross، نويسنده , , Aaron B. Miller، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Explorations of the S1′ subsite of ACE2 via modifications of the P1′ methylene biphenyl moiety of thiol-based metalloprotease inhibitors led to improvements in ACE2 selectivity versus ACE and NEP, while maintaining potent ACE2 inhibition.
Keywords :
metalloproteases , protease inhibitors , thiols , Angiotensin-converting enzyme 2
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
