Title of article
Phenylethynyl-pyrrolo[1,2-a]pyrazine: A new potent and selective tool in the mGluR5 antagonists arena
Author/Authors
Fabrizio Micheli، نويسنده , , Barbara Bertani، نويسنده , , Andrea Bozzoli، نويسنده , , Luca Crippa، نويسنده , , Paolo Cavanni، نويسنده , , Romano Di Fabio، نويسنده , , Daniele Donati، نويسنده , , Paola Marzorati، نويسنده , , Giancarlo Merlo، نويسنده , , Alfredo Paio، نويسنده , , Lorenzo Perugini، نويسنده , , Paola Zarantonello، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
1804
To page
1809
Abstract
The synthesis and the structure activity of a new series of pyrrolo[1,2-a]pyrazine is reported. These molecules are potent and selective non-competitive mGluR5 antagonists and may shed new light on the pattern of substitution tolerated by this receptor.
Keywords
mGluR5 , Metabotropic , receptor , 7-TM , Antagonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799250
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