Title of article
4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties
Author/Authors
Elizabeth M. Doherty، نويسنده , , Daniel Retz، نويسنده , , Narender R. Gavva، نويسنده , , Rami Tamir، نويسنده , , James J.S. Treanor، نويسنده , , Mark H. Norman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
1830
To page
1834
Abstract
8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol (4) and analogs (5–10) were shown to be potent inhibitors of human and rat TRPV1 in vitro with increased solubility over our previous series. Synthesis, SAR, and improvements in metabolic stability and absorption of these compounds are described herein.
Keywords
trpv1 , VR1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799255
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