Title of article
Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones
Author/Authors
Stefan Peukert، نويسنده , , Yingchuan Sun، نويسنده , , Rui Zhang، نويسنده , , Brian Hurley، نويسنده , , Mike Sabio، نويسنده , , Xiaoyu Shen، نويسنده , , Christen Gray، نويسنده , , JoAnn Dzink-Fox، نويسنده , , Jianshi Tao، نويسنده , , Regina Cebula، نويسنده , , Sompong Wattanasin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
1840
To page
1844
Abstract
Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure–activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided.
Keywords
Undecaprenyl pyrophosphate synthase , Antibacterial , UPPS inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799257
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