Title of article
N-Alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents
Author/Authors
Gui-Bai Liang، نويسنده , , Xiaoxia Qian، نويسنده , , Dennis Feng، نويسنده , , Michael Fisher، نويسنده , , Tami Crumley، نويسنده , , Sandra J. Darkin-Rattray، نويسنده , , Paula M. Dulski، نويسنده , , Anne Gurnett، نويسنده , , Penny Sue Leavitt، نويسنده , , Paul A. Liberator، نويسنده , , Andrew S. Misura، نويسنده , , Samantha Samaras، نويسنده , , Tamas Tamas، نويسنده , , Dennis M. Schmatz، نويسنده , , Matthew Wyvratt، نويسنده , , Tesfaye Biftu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2019
To page
2022
Abstract
Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved.
Keywords
PKG , PKG inhibitor , Coccidiosis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799291
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