Synthesis and antimicrobial activity of β-lactam–bile acid conjugates linked via triazole

Synthesis of novel 1,2,3-triazole-linked β-lactam–bile acid conjugates 17–24 using 1,3-dipolar cycloaddition reaction of azido β-lactam and terminal alkyne of bile acids in the presence of Cu(I) catalyst (click chemistry) have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and moderate antibacterial activity against all the tested strains.