Title of article :
Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3
Author/Authors :
Julia Cianci، نويسنده , , Jonathan B. Baell، نويسنده , , Bernard L. Flynn، نويسنده , , Robert W. Gable، نويسنده , , Jorgen A. Mould، نويسنده , , Dharam Paul، نويسنده , , Andrew J. Harvey، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.
Keywords :
Electrophysiology , Kv1.3 , chalcones , Natural product derivatives , Ion channel blockers , Conformational analysis , Molecular modelling , X-ray crystallography
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
