Author/Authors :
M. Jes?s Pérez de Vega، نويسنده , , José Luis Baeza، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده , , Miquel Vila-Perell?، نويسنده , , Carmen Jiménez-Castells، نويسنده , , Ana-maria Simon، نويسنده , , Diana Frechilla، نويسنده , , Joaquin del R?o، نويسنده , , Ricardo Gutiérrez Gallego، نويسنده , , David Andreu، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده ,
Abstract :
A series of constrained pentapeptide analogues of the fragment Aβ31–35 has been prepared using solid phase synthesis protocols. The results of conformational studies and surface plasmon resonance (SPR) experiments seem to indicate that the affinity of these constrained analogues for immobilized Aβ25–35 peptide could be related to their ability to adopt a Leu34N-Ile31O β-turn-like folded conformation.
Keywords :
Turn inducers , Peptide derivatives , surface plasmon resonance , ?-Amyloid
