Author/Authors :
Amy Timmons، نويسنده , , Mark Seierstad، نويسنده , , Rich Apodaca، نويسنده , , Matt Epperson، نويسنده , , Dan Pippel، نويسنده , , Sean Brown، نويسنده , , Leon Chang، نويسنده , , Brian Scott، نويسنده , , Michael Webb، نويسنده , , Sandra R. Chaplan، نويسنده , , J. Guy Breitenbucher، نويسنده ,
Abstract :
Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
Keywords :
pain , endocannabinoid , Fatty acid amide hydrolase , FAAH
