Title of article :
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound
Author/Authors :
Cyrille Tomassi، نويسنده , , Albert Nguyen van Nhien، نويسنده , , José Marco-Contelles، نويسنده , , Jan Balzarini، نويسنده , , Christophe Pannecouque، نويسنده , , Erik De Clercq، نويسنده , , Elena Soriano، نويسنده , , Denis Postel، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The synthesis and the biological evaluation of the anti-HIV-1 activity of TSAO-Boc3T (8) are described. The computational analysis showed that the N-3 Boc group promotes new interactions in the binding site of the enzyme leading to a good inhibitory activity.
Keywords :
Aminonitrile , CSIC reaction , TSAO , ATSAO , Computational study , NNRTI
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
