• Title of article

    Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists. Part I

  • Author/Authors

    Setsuya Sasho، نويسنده , , Takashi Seishi، نويسنده , , Mariko Kawamura، نويسنده , , Ryo Hirose، نويسنده , , Shinichiro Toki، نويسنده , , Jun-ich Shimada، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    4
  • From page
    2288
  • To page
    2291
  • Abstract
    Novel diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for histamine H3 receptor-binding affinities. High-affinity ligands 3d, 3k, and 3n showed potent H3 receptor antagonism and excellent selectivity over human H1, H2 and H4 receptors.
  • Keywords
    Imidazolidinylidene propanedinitrile , Diamine derivatives , Histamine H3 receptor , Antagonist
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    799341