Title of article
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors
Author/Authors
Jinho Lee، نويسنده , , Hwangeun Choi، نويسنده , , Kyoung-Hee Kim، نويسنده , , ShinWu Jeong، نويسنده , , Jong-Wook Park، نويسنده , , Chul-Su Baek، نويسنده , , Sei-Hee Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2292
To page
2295
Abstract
A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
Keywords
CDK inhibitor , 3 , 5-Diaminoindazole , Isothiazolidine-1 , 1-dioxide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799342
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