Title of article
Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines
Author/Authors
Atma P. Dwivedi، نويسنده , , Shailesh Kumar، نويسنده , , Vandana Varshney، نويسنده , , Amar B. Singh، نويسنده , , Arvind K. Srivastava، نويسنده , , Devi P. Sahu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2301
To page
2305
Abstract
A series of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines were synthesized and evaluated for their antihyperglycemic activity. Compounds 3g and 6d exhibited lowering of postprandial plasma glucose by 30.7%, 23.3% in SLM and 25.6%, 25.4% in STZ models respectively which is significant compared to metformin and glybenclamide. Other compounds exhibited moderate to good activity ranging from 19.5% to 32.8% in SLM and 3.26% to 25.4% in STZ models.
Keywords
SLM , STZ , N-Acyl-3-coumarylamines , N-Acyl 2-arylethylammines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799344
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