Title of article
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3
Author/Authors
Martin E. Hayes، نويسنده , , Eric C. Breinlinger، نويسنده , , Grier A. Wallace، نويسنده , , Pintipa Grongsaard، نويسنده , , Wenyan Miao، نويسنده , , Michael J. McPherson، نويسنده , , Robert H. Stoffel، نويسنده , , David W. Green، نويسنده , , Gregory P. Roth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
2414
To page
2419
Abstract
Modification of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization.
Keywords
IP-10 , CXCL10 , Multiple sclerosis , 2-Iminobenzimidazole , Chemokine , Chemokine antagonist , CXCR3 , Benzimidazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799372
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