• Title of article

    Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles

  • Author/Authors

    Caroline M. Reid، نويسنده , , Charles Ebikeme، نويسنده , , MICHAEL P. BARRETT، نويسنده , , Eva-Maria Patzewitz، نويسنده , , Sylke Müller، نويسنده , , David J. Robins، نويسنده , , Andrew Sutherland، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    4
  • From page
    2455
  • To page
    2458
  • Abstract
    A focused library of C2-substituted-1,4,7,10-tetraazacyclododecanes was synthesised and the compounds were tested for their ability to kill trypanosome and malaria parasites. Several compounds showed significant in vitro activity and were selectively active against the parasites over human embryonic kidney cells used as a counter screen.
  • Keywords
    Macrocycles , malaria , Anti-protozoal , Trypanosomes
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    799381

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799381