Author/Authors :
Geraldine C. Harriman، نويسنده , , Matthias Brewer، نويسنده , , Robert Bennett، نويسنده , , Cyrille Kuhn، نويسنده , , Marc Bazin، نويسنده , , Greg Larosa، نويسنده , , Paul Skerker، نويسنده , , Nancy Cochran، نويسنده , , Debra Gallant، نويسنده , , Deborah Baxter، نويسنده , , Dominic Picarella، نويسنده , , Bruce Jaffee، نويسنده , , Jay R. Luly، نويسنده , , Michael J. Briskin، نويسنده ,
Abstract :
A novel series of barbituric acid derivatives were identified as selective inhibitors of α4β7 MAdCAM (mucosal addressin cell adhesion molecule-1) interactions via a high throughput screening exercise. These inhibitors were optimized to submicromolar potencies in whole cell adhesion assays, retaining their selectivity over α4β1 VCAM.
Keywords :
cell adhesion molecule , ?4?7 , Integrin , Barbituric acid , MAdCAM
