Title of article
Synthesis and antimicrobial properties of Monensin A esters
Author/Authors
Adam Huczy?ski، نويسنده , , Joanna Stefa?ska، نويسنده , , Piotr Przybylski، نويسنده , , Bogumil Brzezinski، نويسنده , , Franz Bartl، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2585
To page
2589
Abstract
The esters (2–10) of the ionophore antibiotic Monensin (1) were synthesized by four different methods, which are discussed in detail. These new esters were characterized by various spectroscopic techniques and subsequently tested in the face of their antimicrobial properties. Three derivatives (3, 8 and 10) showed activity against Gram-positive bacteria. Additionally derivative (10) exhibited a relatively low antifungal activity against Candida in contrast to Monensin A.
Keywords
esters , antimicrobial activity , Monensin , Ionophores , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799406
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