Author/Authors :
Annie Mayence، نويسنده , , Aurélie Pietka، نويسنده , , Margaret S. Collins، نويسنده , , Melanie T. Cushion، نويسنده , , Babu L. Tekwani، نويسنده , , Tien L. Huang، نويسنده , , Jean Jacques Vanden Eynde، نويسنده ,
Abstract :
A small library of 2,2′-[(α,ω-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC50 values lower than that determined for pentamidine against L. donovani.
