Title of article :
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping
Author/Authors :
Adrian Hall، نويسنده , , Andy Billinton، نويسنده , , Susan H. Brown، نويسنده , , Anita Chowdhury، نويسنده , , Gerard M.P. Giblin، نويسنده , , Paul Goldsmith، نويسنده , , David N. Hurst، نويسنده , , Alan Naylor، نويسنده , , Sadhana Patel، نويسنده , , Tiziana Scoccitti، نويسنده , , Pamela J. Theobald، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
7
From page :
2684
To page :
2690
Abstract :
We describe the medicinal chemistry approach that generated a novel indole series of EP1 receptor antagonists. The SAR of this new template was evaluated and culminated in the identification of compound 12g which demonstrated in vivo efficacy in a preclinical model of inflammatory pain.
Keywords :
EP1 antagonist , pain , conformational constraint , Scaffold hopping , Lead hopping
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799431
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799431
بازگشت