Title of article :
Development of 2-tbutyl-N-methyl pyrimidones as potent inhibitors of HIV integrase
Author/Authors :
M. Emilia Di Francesco، نويسنده , , Paola Pace، نويسنده , , Fabrizio Fiore، نويسنده , , Francesca Naimo، نويسنده , , Fabio Bonelli، نويسنده , , Michael Rowley، نويسنده , , Vincenzo Summa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A series of novel 2-tbutyl-N-methyl pyrimidone HIV-1 integrase inhibitors have been identified. Optimization of the initial lead resulted in compounds such as 9d and 14a, which showed high levels of activity in cell culture inhibiting viral replication with CIC95 of 10 nM in the presence of 50% normal human serum.
Keywords :
Dihydroxypyrimidines , N-methyl pyrimidones , HIV integrase
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
