Title of article
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
Author/Authors
Catherine Bardelle، نويسنده , , Darren Cross، نويسنده , , Sara Davenport، نويسنده , , Jason G. Kettle، نويسنده , , Eun Jung Ko، نويسنده , , Andrew G. Leach، نويسنده , , Andrew Mortlock، نويسنده , , Jon Read، نويسنده , , Nicola J. Roberts، نويسنده , , Peter Robins، نويسنده , , Emma J. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2776
To page
2780
Abstract
A series of bis-anilinopyrimidines have been identified as potent inhibitors of the tyrosine kinase EphB4. Structural information from two alternative series identified from screening efforts was combined to identify the initial leads.
Keywords
EphB4 , kinase , structure-based design , Lead identification
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799445
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