Title of article :
New tetrazole-based selective anandamide uptake inhibitors
Author/Authors :
Giorgio Ortar، نويسنده , , Aniello Schiano Moriello، نويسنده , , Maria Grazia Cascio، نويسنده , , Luciano De Petrocellis، نويسنده , , Alessia Ligresti، نويسنده , , Enrico Morera، نويسنده , , Marianna Nalli، نويسنده , , Vincenzo Di Marzo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC50 = 2.3–5.1 μM) and selectively over other proteins involved in endocannabinoid action and metabolism.
Keywords :
Anandamide uptake , Endocannabinoids , Tetrazoles , anandamide uptake inhibitors
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
